Transcription occurs in pulses in muscle fibers

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Transcription occurs in pulses in muscle fibers.

We report a novel mechanism of gene regulation in skeletal muscle fibers. Within an individual myofiber nucleus, not all muscle loci are transcriptionally active at a given time and loci are regulated independently. This phenomenon is particularly remarkable because the nuclei within a myofiber share a common cytoplasm. Both endogenous muscle-specific and housekeeping genes and transgenes are r...

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ژورنال

عنوان ژورنال: Genes & Development

سال: 1998

ISSN: 0890-9369

DOI: 10.1101/gad.12.17.2748